With over 57 million Americans at risk for type 2 diabetes, how do clinicians decide whom to bump to the front of the line for preventive care and treatment?  The PreDx Diabetes Risk Score, which employs a few simple blood tests to identify patients at highest risk of developing type 2 diabetes within five years, might help caregivers prioritize their efforts.

Recently, Tethys Bioscience announced the publication of two research articles validating the use of the PreDx Diabetes Risk Score (DSR).  The DSR is a blood test that assesses multiple biomarkers from biological pathways implicated in the development of diabetes.  A biomarker is a detectable substance that indicates that a particular process or event (for example, glucose metabolism) is taking place. Biomarkers can also reveal changes in a biological pathway that correlate with disease progression, or even the risk of disease progression. 

To determine who is at highest risk for developing type 2, the PreDx DSR uses biomarkers from biological pathways and biological events like cardiovascular disease, inflammation, glucose metabolism, and cell death.  The resulting score, which estimates the progression rate of the disease, is claimed to be a better predictor of risk than impaired fasting glucose levels or metabolic syndrome. 

美国有5，700，000人面临2型糖尿病的危险，临床医生们如何决定谁应该优先享受预防保健和治疗？5年来，PreDx Diabetes Risk Score (DSR).对2型糖尿病的高危患者，进行了一些简单的血液测试，有助于解决这一问题。

最近Tethys Bioscience特瑟生物科学发布了使用DSR有效的两篇研究文章。DSR 是一种血液检测物，通过与疾病发展有关的生物进程，对多种生物标志物进行评估。生物标志物是一种检测物质，指示一个正在发生的特殊过程或结果（例如，葡萄糖代谢）。生物标志物还能显示生物进程与疾病相关进展的变化，或者甚至是疾病进展中的危险。

确定谁是2型糖尿病的高危人群，DSR 使用从生物进程和结果中，诸如，心血管疾病，炎症，葡萄糖代谢和细胞死亡等，使用生物标志物。评价疾病发展比率的结果评分，被认为是比空腹血糖受损水平或代谢综合症更好的一种风险指示物

DSR 可能用于已经表现出危险因素的患者，包括高葡萄糖水平，肥胖，缺乏活动，糖尿病家族史，高血压，胆固醇异常，代谢综合症或妊娠期糖尿病史。利用DRS显示的有关2型糖尿病的危险因素，保健人员能够推荐从简单的生活方式改变，如锻炼，减肥和饮食到药物，一整套的预防措施。

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